Infectious mononucleosis, associated with herpes virus type 6
Published: 18.11.08 Updated: 18.11.2008 13:01:15
Novosad EV, Shamsheva OV, Lvov ND, et al. Infectious mononucleosis, associated with herpes virus type 6. Detskie Infektsii (Childhood infections) 2008; 1:36-38.
Novosad E.V. et al studied clinical features of the infectious mononucleosis associated with human herpes virus type 6. Altogether, 159 children aged 8 months-14 years were studied. Eighty-three (52%) of them had Epstein-Barr virus associated infectious mononucleosis, 32 (20%) had herpes virus type 6 associated infectious mononucleosis, 3 (2%) had cytomegalovirus associated infectious mononucleosis and 41 (26%) had co-infections, among which herpes virus type 6 was present in 35 (22%) of cases.
The authors conclude that human herpes virus type 6 infections including co-infections comprise almost a half of all infectious mononucleosis cases; clinical picture of human herpes virus type 6 associated infectious mononucleosis does not differ from the clinical picture of the infectious mononucleosis associated with Epstein-Barr virus; heterophile antibodies (IgM) test is always negative in infectious mononucleosis associated with human herpes virus type 6. The authors suggest that patients with infectious mononucleosis should be tested for herpes virus types 4, 5 and 6 by using polymerase chain reaction and enzyme immunoassays tests.